George Lopez continues as plant manager at a Los Angeles airplane-parts factory, while his affable compadre, Ernie (Valente Rodriguez), still teases him. George and his devoted wife, Angie (Constance Marie), recently chose to renew their wedding vows, but her drive to build a wedding planning business has placed a huge financial burden on the family.
While Angie gets some guidance from her father, Vic (Emiliano Diez), George's biggest test is his mother, Benny (Belita Moreno). After rediscovering his father, plus learning of a long-lost sister, George now wonders what other lies his mother has told him.
Meanwhile, 16-year-old Carmen (Masiela Lusha) has left her parents at a total loss, and 13-year-old Max (Luis Armand Garcia) continues to struggle with dyslexia and constantly tests his parents' limits by associating with the wrong friends. More lemons, more lemonade for George.