Separated from his wife Emma, amnesiac John Murdoch (Rufus Sewell) awakens alone in a strange hotel to learn he is wanted for a series of brutal killings.
They built the city to see what makes us tick. Last night one of us went off. What if you woke one morning to realize that every memory, every emotion, every fact you believed true about your life had been manufactured by someone else and placed in your mind?
In this fascinating and provocative science fiction tale, John Murdoch—wanted for a series of brutal murders—realizes that everything he believes about himself is a lie. Murdoch's bittersweet childhood, his love for his estranged wife (Jennifer Connelly) and the hideous series of murders are the creation of a group of shadowy creatures known only as "The Strangers," who manipulate minds for their own ends.
Alone, with his newfound awareness, Murdoch begins to fight back. William Hurt is the evil Detective hunting him down, and Kiefer Sutherland is the doctor helping him stay one step ahead of his adversaries.